Membrane disordering effects of beta-amyloid peptides.
نویسندگان
چکیده
The interaction of Abeta with synaptosomal plasma membranes decreases membrane fluidity. Using model membrane/liposome systems the interaction of Abeta with specific lipids (e.g. phospholipids, gangliosides, cholesterol) has been defined. The formation of the beta-sheet structure of Abeta when undergoing peptide aggregation is important for Abeta's membrane perturbing properties. This effect can be correlated with the peptide length of Abeta, the longer Abeta1-42 having the greatest effect on membrane fluidity and on neurotoxicity.
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ورودعنوان ژورنال:
- Biochemical Society transactions
دوره 29 Pt 4 شماره
صفحات -
تاریخ انتشار 2001